Objective: Vaccines are an effective means to reduce the spread of diseases, but they are sometimes met with hesitancy that needs to be understood.
Methods: In this study, we analysed data from a large, cross-country survey conducted between June and August 2021 in 43 countries (N = 15,740) to investigate the roles of trust in government and science in shaping vaccine attitudes and willingness to be vaccinated.
Results: We found that, despite significant variability between countries, both forms of institutional trust were associated with a higher willingness to receive a COVID-19 vaccine. Further, we found that conspiratorial thinking and anti-expert sentiments predicted reduced trust in government and science, respectively, and that trust mediated the relationship between these beliefs and ultimate vaccine attitudes. Although most countries displayed similar relationships between conspiratorial thinking and anti-expert sentiments, trust, and vaccine attitudes, we identified three countries (Brazil, Honduras, and Russia) with significantly differing effects of these variables.
Conclusions: We discuss and propose various additional local factors that future research should consider to understand how trust and attitudes towards governmental and scientific institutions may shape individuals’ ultimate vaccine attitudes and decisions.